Endocrine Abstracts

Background and aims: The fat mass and obesity associated gene (FTO) was identified as a gene with strong obesity related traits nevertheless the exact mechanism is still unknown. Our aim was to study the possible effects of FTO risk haplotype on anthropometric data and metabolic and hormonal parameters in lean women (to eliminate the influence of BMI) and to evaluate the effect of hormone contraception (HC).Materials and methods: The SNPs r...

Melanocortin-4 receptor (MC4R) gene is expressed in the brain and has been implicated in mediating most of the effects of melanocortin on food intake and energy expenditure. Common variants of MC4R gene are associated with fat mass, weight, risk of obesity and insulin resistance in several populations.We investigated if rs12970134 A/G is associated with obesity and studied its possible metabolic effects.Polymorphism was assesed by ...

Detailed information on adrenal function in autoimmune Type 1 diabetes with onset in adults is still lacking. This work aimed at gathering own data on adrenal response to low-dose (1 μg) ACTH in blood and saliva.Twenty-three diabetics were investigated; age 44±10 yrs (mean ± S.D.), age at diagnosis 28.5±10 yr, disease duration 15±8 yr, BMI 24.5±2.7 kg/cm2, HbA1c 7.2±1.2%....

Detailed information on adrenal function in autoimmune Type 1 diabetes with onset in adult age is still missing. This work compared diabetics with low response (LR) to diabetics with normal response (NR) to low dose ACTH test and control group (C).Thirty-two diabetics were investigated; LR (n=16), NR (n=16), age 44±10 years (mean±S.D.), age at diagnosis 28.5±10 years, disease duration 15±8 years, BMI 24.5&...